Sequestration of Proteins
In addition to its role in ribosomal biogenesis, the nucleolus is known to capture and immobilize proteins, a process known as nucleolar sequestration. Proteins that are sequestered in the nucleolus are unable to diffuse and to interact with their binding partners. Targets of this post-translational regulatory mechanism include VHL, PML, MDM2, RelA, HAND1 and hTERT, among many others. It is now known that noncoding RNAs originating from intergenic regions of the nucleolus are responsible for this phenomenon.
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