Orthogonal System
It has been proposed and studied both theoretically and experimentally the possibility of implementing an orthogonal system inside cells independent of the cellular genetic material in order to make a completely safe system, with the possible increase in encoding potentials Several groups have focused on different aspects:
- novel backbones and base pairs as discussed above
- XNA (Xeno Nucleic Acid) artificial replication/transcription polymerases starting generally from T7 RNA polymerase
- ribosomes (16S sequences with altered anti Shine-Dalgarno sequence allowing the translation of only orthogonal mRNA with a matching altered Shine-Dalgarno sequence)
- novel tRNA encoding non-natural aminoacids. See Expanded genetic code
Read more about this topic: Nucleic Acid Analogues
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