Family Members
The following is a list of the 48 known human nuclear receptors categorized according to sequence homology.
| Subfamily | Group | Member | ||||||
|---|---|---|---|---|---|---|---|---|
| NRNC Symbol | Abbreviation | Name | Gene | Ligand(s) | ||||
| 1 | Thyroid Hormone Receptor-like | A | Thyroid hormone receptor | NR1A1 | TRα | Thyroid hormone receptor-α | THRA | thyroid hormone |
| NR1A2 | TRβ | Thyroid hormone receptor-β | THRB | |||||
| B | Retinoic acid receptor | NR1B1 | RARα | Retinoic acid receptor-α | RARA | vitamin A and related compounds | ||
| NR1B2 | RARβ | Retinoic acid receptor-β | RARB | |||||
| NR1B3 | RARγ | Retinoic acid receptor-γ | RARG | |||||
| C | Peroxisome proliferator-activated receptor | NR1C1 | PPARα | Peroxisome proliferator-activated receptor-α | PPARA | fatty acids, prostaglandins | ||
| NR1C2 | PPAR-β/δ | Peroxisome proliferator-activated receptor-β/δ | PPARD | |||||
| NR1C3 | PPARγ | Peroxisome proliferator-activated receptor-γ | PPARG | |||||
| D | Rev-ErbA | NR1D1 | Rev-ErbAα | Rev-ErbAα | NR1D1 | heme | ||
| NR1D2 | Rev-ErbAβ | Rev-ErbAα | NR1D2 | |||||
| F | RAR-related orphan receptor | NR1F1 | RORα | RAR-related orphan receptor-α | RORA | cholesterol, ATRA | ||
| NR1F2 | RORβ | RAR-related orphan receptor-β | RORB | |||||
| NR1F3 | RORγ | RAR-related orphan receptor-γ | RORC | |||||
| H | Liver X receptor-like | NR1H3 | LXRα | Liver X receptor-α | NR1H3 | oxysterols | ||
| NR1H2 | LXRβ | Liver X receptor-β | NR1H2 | |||||
| NR1H4 | FXR | Farnesoid X receptor | NR1H4 | |||||
| I | Vitamin D receptor-like | NR1I1 | VDR | Vitamin D receptor | VDR | vitamin D | ||
| NR1I2 | PXR | Pregnane X receptor | NR1I2 | xenobiotics | ||||
| NR1I3 | CAR | Constitutive androstane receptor | NR1I3 | androstane | ||||
| X | NRs with two DNA binding domains | NR1X1 | 2DBD-NRα | |||||
| NR1X2 | 2DBD-NRβ | |||||||
| NR1X3 | 2DBD-NRγ | |||||||
| 2 | Retinoid X Receptor-like | A | Hepatocyte nuclear factor-4 | NR2A1 | HNF4α | Hepatocyte nuclear factor-4-α | HNF4A | fatty acids |
| NR2A2 | HNF4γ | Hepatocyte nuclear factor-4-γ | HNF4G | |||||
| B | Retinoid X receptor | NR2B1 | RXRα | Retinoid X receptor-α | RXRA | retinoids | ||
| NR2B2 | RXRβ | Retinoid X receptor-β | RXRB | |||||
| NR2B3 | RXRγ | Retinoid X receptor-γ | RXRG | |||||
| C | Testicular receptor | NR2C1 | TR2 | Testicular receptor 2 | NR2C1 | |||
| NR2C2 | TR4 | Testicular receptor 4 | NR2C2 | |||||
| E | TLX/PNR | NR2E1 | TLX | Homologue of the Drosophila tailless gene | NR2E1 | |||
| NR2E3 | PNR | Photoreceptor cell-specific nuclear receptor | NR2E3 | |||||
| F | COUP/EAR | NR2F1 | COUP-TFI | Chicken ovalbumin upstream promoter-transcription factor I | NR2F1 | |||
| NR2F2 | COUP-TFII | Chicken ovalbumin upstream promoter-transcription factor II | NR2F2 | |||||
| NR2F6 | EAR-2 | V-erbA-related | NR2F6 | |||||
| 3 | Estrogen Receptor-like | A | Estrogen receptor | NR3A1 | ERα | Estrogen receptor-α | ESR1 | estrogens |
| NR3A2 | ERβ | Estrogen receptor-β | ESR2 | |||||
| B | Estrogen related receptor | NR3B1 | ERRα | Estrogen-related receptor-α | ESRRA | |||
| NR3B2 | ERRβ | Estrogen-related receptor-β | ESRRB | |||||
| NR3B3 | ERRγ | Estrogen-related receptor-γ | ESRRG | |||||
| C | 3-Ketosteroid receptors | NR3C1 | GR | Glucocorticoid receptor | NR3C1 | cortisol | ||
| NR3C2 | MR | Mineralocorticoid receptor | NR3C2 | aldosterone | ||||
| NR3C3 | PR | Progesterone receptor | PGR | progesterone | ||||
| NR3C4 | AR | Androgen receptor | AR | testosterone | ||||
| 4 | Nerve Growth Factor IB-like | A | NGFIB/NURR1/NOR1 | NR4A1 | NGFIB | Nerve Growth factor IB | NR4A1 | |
| NR4A2 | NURR1 | Nuclear receptor related 1 | NR4A2 | |||||
| NR4A3 | NOR1 | Neuron-derived orphan receptor 1 | NR4A3 | |||||
| 5 | Steroidogenic Factor-like | A | SF1/LRH1 | NR5A1 | SF1 | Steroidogenic factor 1 | NR5A1 | phosphatidylinositols |
| NR5A2 | LRH-1 | Liver receptor homolog-1 | NR5A2 | phosphatidylinositols | ||||
| 6 | Germ Cell Nuclear Factor-like | A | GCNF | NR6A1 | GCNF | Germ cell nuclear factor | NR6A1 | |
| 0 | Miscellaneous | B | DAX/SHP | NR0B1 | DAX1 | Dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1 | NR0B1 | |
| NR0B2 | SHP | Small heterodimer partner | NR0B2 | |||||
Read more about this topic: Nuclear Receptor
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