The Nociceptive Trigeminal Inhibition Tension Suppression System is a device that is claimed to prevent headache and migraine by reducing night-time occlusal clenching. This often intense nocturnal activity is purported to lead to a hyperactivity of the trigeminal nerve, often triggering typical migraine events. The objective of the NTI is to relax the muscles involved in clenching and mastication, thus diminishing the chances for migraines and tension headaches to develop.
The NTI is a small transparent plastic device which is, in its most widely used form, worn over the two front teeth at night to prevent contact of the canines and molars. It is normally fitted by a dentist trained in the technique. It does not involve any drugs, shots, or surgery.
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—Catherine E. Beecher (1800–1878)