History
Since its establishment in 1946, the Japanese Society of Chemotherapy (JSC) has been and currently is involved in the development of synthetic antibacterial agents from nalidixic acid and pipemidic acid, leading to new quinolones. Subsequent work led to the birth of a new era with the introduction of norfloxacin as the first new quinolone in Japan in 1984 and then in many other countries throughout the world. Since the discovery of norfloxacin (1980), around 10,000 new analogues have been described.
Norfloxacin was first patented in 1979. Kyorin granted Merck & Company, Inc., an exclusive license (in certain countries, including the United States), to import and distribute Norfloxacin under the brand name Noroxin. The U.S. Food and Drug Administration (FDA) approved Noroxin for distribution in the United States on October 31, 1986. Since the approval of Noroxin in 1986, there have been numerous upgrades to the warning sections of the package inserts, as well as recent restrictions placed upon the use of Noroxin to treat urinary tract infections (UTIs).
Read more about this topic: Norfloxacin
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“The history of every country begins in the heart of a man or a woman.”
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