Dosing
The status of the patient’s renal function and hepatic function should also be taken into consideration to avoid an accumulation that may lead to a fatal drug overdose. Norfloxacin is eliminated primarily by renal excretion. However, the drug is also metabolized and partially cleared through the liver and the intestine. Modification of the dosage is recommended using the table found within the package insert for those with impaired liver or kidney function. (Particularly for patients with severe renal dysfunction.) However, since the drug is known to be substantially excreted by the kidneys, the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Additional caution is warranted in the elderly population as well. The duration of treatment depends upon the severity of infection and the usual duration is anywhere from 3 to 28 days.
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