Noggin (protein)

Noggin (protein)

Identifiers Symbols NOG; SYM1; SYNS1 External IDs OMIM: 602991 MGI: 104327 HomoloGene: 3979 GeneCards: NOG Gene

Gene Ontology
Molecular function	• cytokine binding • protein homodimerization activity
Cellular component	• extracellular region • extracellular space
Biological process	• negative regulation of transcription from RNA polymerase II promoter • skeletal system development • osteoblast differentiation • in utero embryonic development • endoderm formation • mesoderm formation • epithelial to mesenchymal transition • neural plate morphogenesis • neural tube closure • nervous system development • motor neuron axon guidance • dorsal/ventral pattern formation • spinal cord development • cell differentiation in hindbrain • pituitary gland development • negative regulation of cell migration • BMP signaling pathway • negative regulation of BMP signaling pathway • somatic stem cell maintenance • wound healing • middle ear morphogenesis • embryonic digit morphogenesis • negative regulation of apoptotic process • negative regulation of osteoblast differentiation • positive regulation of transcription from RNA polymerase II promoter • axial mesoderm development • notochord morphogenesis • embryonic skeletal system development • negative regulation of astrocyte differentiation • positive regulation of epithelial cell proliferation • cartilage development • negative regulation of cardiac muscle cell proliferation • limb development • embryonic skeletal joint morphogenesis • negative regulation of cytokine activity • face morphogenesis • negative regulation of pathway-restricted SMAD protein phosphorylation • lung morphogenesis • prostatic bud formation • ureteric bud formation • fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation • negative regulation of cartilage development • somite development • cellular response to BMP stimulus • negative regulation of canonical Wnt receptor signaling pathway • positive regulation of branching involved in ureteric bud morphogenesis • positive regulation of glomerulus development • regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
Sources: Amigo / QuickGO

Orthologs Species Human Mouse Entrez 9241 18121 Ensembl ENSG00000183691 ENSMUSG00000048616 UniProt Q13253 P97466 RefSeq (mRNA) NM_005450 NM_008711 RefSeq (protein) NP_005441 NP_032737 Location (UCSC) Chr 17:
54.67 – 54.67 Mb Chr 11:
89.3 – 89.3 Mb PubMed search

Noggin, also known as NOG, is a protein which in humans is encoded by the NOG gene.

Noggin inhibits TGF-β signal transduction by binding to TGF-β family ligands and preventing them from binding to their corresponding receptors. Noggin plays a key role in neural induction by inhibiting BMP4, along with other TGF-β signaling inhibitors such as chordin and follistatin. Mouse knockout experiments have demonstrated that noggin also plays a crucial role in learning, cognition, bone development, joint formation, and neural tube fusion.