Nicotinic Agonist - Nicotinic Versus Muscarinic Activity

Nicotinic Versus Muscarinic Activity

Comparison of cholinergic agonists
Substance Receptor specificity Hydrolysis by
acetylcholinesterase
Comments
Muscarinic Nicotinic
Choline +++ +++ ++ Essential nutrient
Acetylcholine +++ +++ +++ Endogenous ligand
Carbachol ++ +++ - Used in the treatment of glaucoma
Methacholine +++ + ++
Bethanechol +++ - - Used in bladder and
gastrointestinal hypotonia.
Muscarine +++ - - Natural alkaloid found in certain mushrooms. Cause of mushroom poisoning
Nicotine - +++ - Natural alkaloid found in the tobacco plant.
Pilocarpine ++ - - Used in glaucoma
Oxotremorine ++ - -

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