Nicotinic Versus Muscarinic Activity
| Comparison of cholinergic agonists | ||||
|---|---|---|---|---|
| Substance | Receptor specificity | Hydrolysis by acetylcholinesterase |
Comments | |
| Muscarinic | Nicotinic | |||
| Choline | +++ | +++ | ++ | Essential nutrient |
| Acetylcholine | +++ | +++ | +++ | Endogenous ligand |
| Carbachol | ++ | +++ | - | Used in the treatment of glaucoma |
| Methacholine | +++ | + | ++ | |
| Bethanechol | +++ | - | - | Used in bladder and gastrointestinal hypotonia. |
| Muscarine | +++ | - | - | Natural alkaloid found in certain mushrooms. Cause of mushroom poisoning |
| Nicotine | - | +++ | - | Natural alkaloid found in the tobacco plant. |
| Pilocarpine | ++ | - | - | Used in glaucoma |
| Oxotremorine | ++ | - | - | |
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