Nicotinic Versus Muscarinic Activity
Comparison of cholinergic agonists | ||||
---|---|---|---|---|
Substance | Receptor specificity | Hydrolysis by acetylcholinesterase |
Comments | |
Muscarinic | Nicotinic | |||
Choline | +++ | +++ | ++ | Essential nutrient |
Acetylcholine | +++ | +++ | +++ | Endogenous ligand |
Carbachol | ++ | +++ | - | Used in the treatment of glaucoma |
Methacholine | +++ | + | ++ | |
Bethanechol | +++ | - | - | Used in bladder and gastrointestinal hypotonia. |
Muscarine | +++ | - | - | Natural alkaloid found in certain mushrooms. Cause of mushroom poisoning |
Nicotine | - | +++ | - | Natural alkaloid found in the tobacco plant. |
Pilocarpine | ++ | - | - | Used in glaucoma |
Oxotremorine | ++ | - | - |
Read more about this topic: Nicotinic Agonist
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