Species Distribution and Evolution
In addition to mammals, NF-κB is found in a number of simple animals as well. These include cnidarians (such as sea anemones, coral and hydra), porifera (sponges), the single-celled eukaryote Capsaspora owczarzaki and insects (such as moths, mosquitoes and fruitflies). The sequencing of the genomes of the mosquitoes A. aegypti and A. gambiae, and the fruitfly D. melanogaster has allowed comparative genetic and evolutionary studies on NF-κB. In those insect species, activation of NF-κB is triggered by the Toll pathway (which evolved independently in insects and mammals) and by the Imd (immune deficiency) pathway.
Read more about this topic: NFKB
Famous quotes containing the words species, distribution and/or evolution:
“Not only does every animal live at the expense of some other animal or plant, but the very plants are at war.... The individuals of a species are like the crew of a foundered ship, and none but good swimmers have a chance of reaching the land.”
—Thomas Henry Huxley (1825–95)
“My topic for Army reunions ... this summer: How to prepare for war in time of peace. Not by fortifications, by navies, or by standing armies. But by policies which will add to the happiness and the comfort of all our people and which will tend to the distribution of intelligence [and] wealth equally among all. Our strength is a contented and intelligent community.”
—Rutherford Birchard Hayes (1822–1893)
“Analyze theory-building how we will, we all must start in the middle. Our conceptual firsts are middle-sized, middle-distanced objects, and our introduction to them and to everything comes midway in the cultural evolution of the race.”
—Willard Van Orman Quine (b. 1908)