Non-drug Inhibitors
Many natural products (including anti-oxidants) that have been promoted to have anti-cancer and anti-inflammatory activity have also been shown to inhibit NF-κB. There is a controversial US patent (US patent 6,410,516) that applies to the discovery and use of agents that can block NF-κB for therapeutic purposes. This patent is involved in several lawsuits, including Ariad v. Lilly. Recent work by Karin, Ben-Neriah and others has highlighted the importance of the connection between NF-κB, inflammation, and cancer, and underscored the value of therapies that regulate the activity of NF-κB.
Extracts from a number of herbs and dietary plants are efficient inhibitors of NF-kappaB activation in vitro.
The circumsporozoite protein of Plasmodium falciparum has been shown to be an inhibitor of NF-κB.
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