Major Intersections
| County | Location | Mile | km | Destinations | Notes |
|---|---|---|---|---|---|
| Cortland |
Cortlandville | 0.00 | 0.00 | NY 13 (Tompkins Street) | |
| 1.61 | 2.59 | NY 222 | |||
| 3.80 | 6.12 | I-81 | Exit 12 (I-81) via unsigned NY 930Q | ||
| Village of Homer | 4.22 | 6.79 | NY 90 (Cayuga Street) | ||
| 4.99 | 8.03 | NY 41 (Clinton Street) | |||
| Preble | 12.69 | 20.42 | I-81 | Exit 13 (I-81) | |
| Onondaga |
Town of Tully | 16.56 | 26.65 | US 11 / NY 80 |
Read more about this topic: New York State Route 281
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