New York State Route 22

New York State Route 22 (NY 22) is a north–south state highway in eastern New York in the United States. It runs parallel to the state's eastern edge from the outskirts of New York City to the Canadian border. At 341 miles (549 km), it is the state's longest north–south route and the third longest overall, after NY 5 and NY 17. Many of the state's major east–west roads intersect with Route 22 just before crossing the state line into the neighboring New England states.

Almost all of Route 22 is a two-lane rural road that only passes through small villages and hamlets. The exceptions are its southern end in the heavily populated Bronx and lower Westchester County, and a section of that runs through the city of Plattsburgh near the northern end. The rural landscape that the road passes through varies from horse country and views of the picturesque reservoirs of the New York City watershed in the northern suburbs of the city, to dairy farms further upstate in the hilly Taconics and Berkshires, to the undeveloped, heavily forested Adirondack Park along the shores of Lake Champlain. An 86-mile (138 km) section from Fort Ann to Keeseville is part of the All-American Road known as the Lakes to Locks Passage.

The southernmost section of the road was known as the White Plains Post Road in the eighteenth and nineteenth centuries, a major highway connecting New York City to White Plains, the Westchester county seat. Route 22 in its modern form was established in 1930 as one of the principal routes from New York City to Canada.