Cast
- Wesley Snipes – Nino Brown; an arrogant, smart drug kingpin who uses his ideas into selling cocaine and crack. He was the murderer of Scotty's mother.
- Ice-T – Scotty Appleton; an New York Police detective who vows to bring Nino down as retribution since Nino was clearly responsible for Scotty's mother's death.
- Judd Nelson – Nick Peretti; Scotty's partner in the CMB investigation.
- Allen Payne – Gerald "Gee Money" Wells; Nino's childhood friend and the second-in-command of the Cash Money Brother's (CMB).
- Chris Rock – Benny "Pookie" Robinson; A former stick-up kid who becomes homeless and poor after Scotty shoots him in the ankle. He eventually becomes an police informant and infiltrates the CMB at the Carter until he was caught sneaking drugs and killed.
- Mario Van Peebles – Stone; the leader of the CMB police operation.
- Michael Michele – Selina Thomas; Nino's girlfriend who becomes extremely jealous when Nino falls for Gee Money's girlfriend.
- Bill Nunn – Duh Duh Duh Man; the CMB enforcer and Nino's personal bodyguard.
- Russell Wong – Park; an police officer who has Pookie use high-technology for his infiltration.
- Vanessa A. Williams – Keisha; a female gang member of the CMB.
- Bill Cobbs – Old man; an elderly man who is against Nino's crimes towards the city. At the end of the film, he kills Nino when he exits the courtroom by shooting him through the chest and Nino falls down to his death.
- Christopher Williams – Kareem Akbar; A gang member of the CMB.
- Tracy Camilla Johns – Uniqua; Gee Money's girlfriend who falls for Nino.
- Anthony DeSando – Frankie Needles In His Arms; A mobster who has connections towards the CMB from his boss, Don Armeteo. Around the film, Nick and Scotty forces him to bring Gee Money to let Scotty join the gang.
- Nick Ashford – Rev. Oates
- Eek-a-Mouse – Fat Smitty
- Keith Sweat – Singer at Wedding
- Flavor Flav - Himself
- Christopher Michael - Bailiff
- Tina Lifford as recovering addict
- Beverly Mickins as recovering addict
- Kelly Jo Minter as recovering addict
- David Kinnecome -pimp number two
- Seth Kean - Julius the Ho
Read more about this topic: New Jack City
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