Neutrophil Cytosolic Factor 1

Neutrophil Cytosolic Factor 1

Identifiers Symbols NCF1; NCF1A; NOXO2; SH3PXD1A; p47phox External IDs OMIM: 608512 MGI: 97283 HomoloGene: 30964 ChEMBL: 1613743 GeneCards: NCF1 Gene

Gene Ontology
Molecular function	• GTPase activity • protein binding • GTP binding • electron carrier activity • superoxide-generating NADPH oxidase activity • SH3 domain binding • phosphatidylinositol binding
Cellular component	• cytosol • phagolysosome • NADPH oxidase complex
Biological process	• response to yeast • antigen processing and presentation of peptide antigen via MHC class I • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • respiratory burst involved in defense response • GTP catabolic process • protein targeting to membrane • leukotriene metabolic process • superoxide metabolic process • inflammatory response • cellular defense response • cell communication • cell proliferation • superoxide anion generation • antigen processing and presentation of exogenous peptide antigen via MHC class I • innate immune response • respiratory burst • negative regulation of smooth muscle contraction • hydrogen peroxide biosynthetic process • interaction with host • neutrophil mediated killing of gram-positive bacterium • neutrophil mediated killing of fungus • phagosome maturation
Sources: Amigo / QuickGO

Orthologs Species Human Mouse Entrez 653361 17969 Ensembl ENSG00000158517 ENSMUSG00000015950 UniProt P14598 Q09014 RefSeq (mRNA) NM_000265 NM_010876 RefSeq (protein) NP_000256 NP_035006 Location (UCSC) Chr 7:
74.19 – 74.2 Mb Chr 5:
134.22 – 134.23 Mb PubMed search

Neutrophil cytosol factor 1 is a protein that in humans is encoded by the NCF1 gene.

The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. p47 is vital to the activation of NADPH oxidase. P47 becomes heavily phosphorylated