Neutrophil Cytosolic Factor 1
| Gene Ontology | |
|---|---|
| Molecular function | • GTPase activity • protein binding • GTP binding • electron carrier activity • superoxide-generating NADPH oxidase activity • SH3 domain binding • phosphatidylinositol binding |
| Cellular component | • cytosol • phagolysosome • NADPH oxidase complex |
| Biological process | • response to yeast • antigen processing and presentation of peptide antigen via MHC class I • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • respiratory burst involved in defense response • GTP catabolic process • protein targeting to membrane • leukotriene metabolic process • superoxide metabolic process • inflammatory response • cellular defense response • cell communication • cell proliferation • superoxide anion generation • antigen processing and presentation of exogenous peptide antigen via MHC class I • innate immune response • respiratory burst • negative regulation of smooth muscle contraction • hydrogen peroxide biosynthetic process • interaction with host • neutrophil mediated killing of gram-positive bacterium • neutrophil mediated killing of fungus • phagosome maturation |
| Sources: Amigo / QuickGO | |
74.19 – 74.2 Mb
134.22 – 134.23 Mb
Neutrophil cytosol factor 1 is a protein that in humans is encoded by the NCF1 gene.
The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. p47 is vital to the activation of NADPH oxidase. P47 becomes heavily phosphorylated
Read more about Neutrophil Cytosolic Factor 1: Interactions
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