Neurotransmitter Transporters - Types

Types

Specific types of neurotransmitter transporters include the following:

  • Glutamate/aspartate transporters, including:
    • Excitatory amino acid transporter 1 (EAAT1)
    • Excitatory amino acid transporter 2 (EAAT2)
    • Excitatory amino acid transporter 3 (EAAT3)
    • Excitatory amino acid transporter 4 (EAAT4)
    • Excitatory amino acid transporter 5 (EAAT5)
    • Vesicular glutamate transporter 1 (VGLUT1)
    • Vesicular glutamate transporter 2 (VGLUT2)
    • Vesicular glutamate transporter 3 (VGLUT3)
  • GABA transporters, including:
    • GABA transporter type 1 (GAT1)
    • GABA transporter type 2 (GAT2)
    • GABA transporter type 3 (GAT3)
    • Betaine transporter (BGT1)
    • Vesicular GABA transporter (VGAT)
  • Glycine transporters, including:
    • Glycine transporter type 1 (GlyT1)
    • Glycine transporter type 2 (GlyT2)
  • Monoamine transporters, including:
    • Dopamine transporter (DAT)
    • Norepinephrine transporter (NET)
    • Serotonin transporter (SERT)
    • Vesicular monoamine transporter 1 (VMAT1)
    • Vesicular monoamine transporter 2 (VMAT2)
  • Adenosine transporters, including:
    • Equilibrative nucleoside transporter 1 (ENT1)
    • Equilibrative nucleoside transporter 2 (ENT2)
    • Equilibrative nucleoside transporter 3 (ENT3)
    • Equilibrative nucleoside transporter 4 (ENT4)
  • Vesicular acetylcholine transporter (VAChT)

Note that there is no plasmalemmal acetylcholine transporter, as acetylcholine is terminated via rapid metabolism into choline by cholinesterase enzymes, and choline is subsequently transported back into the cell and reconverted into acetylcholine.

Transporters associated with histamine and the endocannabinoids have not yet been identified.

Read more about this topic:  Neurotransmitter Transporters

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