Clinical Significance
Antidepressants such as SSRIs, SNRIs and TCAs suppress the activity of serotonin and/or norepinephrine transporters, preventing the reuptake of targeted neurotransmitters from the synaptic cleft.
Psychostimulants like cocaine, amphetamines, and methylphenidate act by inhibiting and/or reversing the dopamine and norepinephrine transporters. Some dissociatives like phencyclidine and ketamine are also dopamine transporter blockers.
Tiagabine, a drug used as an anticonvulsant, acts by inhibiting the GABA transporter 1.
Read more about this topic: Neurotransmitter Transporters
Famous quotes containing the word significance:
“The hysterical find too much significance in things. The depressed find too little.”
—Mason Cooley (b. 1927)