Clinical Significance
Antidepressants such as SSRIs, SNRIs and TCAs suppress the activity of serotonin and/or norepinephrine transporters, preventing the reuptake of targeted neurotransmitters from the synaptic cleft.
Psychostimulants like cocaine, amphetamines, and methylphenidate act by inhibiting and/or reversing the dopamine and norepinephrine transporters. Some dissociatives like phencyclidine and ketamine are also dopamine transporter blockers.
Tiagabine, a drug used as an anticonvulsant, acts by inhibiting the GABA transporter 1.
Read more about this topic: Neurotransmitter Transporters
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“History is the interpretation of the significance that the past has for us.”
—Johan Huizinga (1872–1945)