Ionotropic Receptors: Neurotransmitter-Gated Ion Channels
Ligand-gated ion channels (LGICs) are one type of ionotropic receptor or channel-linked receptor. They are a group of transmembrane ion channels that are opened or closed in response to the binding of a chemical messenger (i.e., a ligand), such as a neurotransmitter.
The binding site of endogenous ligands on LGICs protein complexes are normally located on a different portion of the protein (an allosteric binding site) compared to where the ion conduction pore is located. The direct link between ligand binding and opening or closing of the ion channel, which is characteristic of ligand-gated ion channels, is contrasted with the indirect function of metabotropic receptors, which use second messengers. LGICs are also different from voltage-gated ion channels (which open and close depending on membrane potential), and stretch-activated ion channels (which open and close depending on mechanical deformation of the cell membrane).
Read more about this topic: Neurotransmitter Receptor
Famous quotes containing the word channels:
“Not too many years ago, a child’s experience was limited by how far he or she could ride a bicycle or by the physical boundaries that parents set. Today ... the real boundaries of a child’s life are set more by the number of available cable channels and videotapes, by the simulated reality of videogames, by the number of megabytes of memory in the home computer. Now kids can go anywhere, as long as they stay inside the electronic bubble.”
—Richard Louv (20th century)