Reversal
The effect of non-depolarizing neuromuscular-blocking drugs may be reversed with anticholinesterases, neostigmine, and edrophonium, as commonly used examples. Of these, edrophonium has a faster onset of action than neostigmine, but it is unreliable when used to antagonize deep neuromuscular block. Anticholinesterases increase the amount of acetylcholine in the neuromuscular junction, so a prerequisite for their effect is that the neuromuscular block is not complete, because in case every acetylcholine receptor is blocked then it does not matter how much acetylcholine is present.
Sugammadex is a newer drug for reversing neuromuscular block by rocuronium in general anaesthesia. It is the first selective relaxant binding agent (SRBA).
Read more about this topic: Neuromuscular-blocking Drug
Famous quotes containing the word reversal:
“Perversity depends on reversal and substitution.”
—Mason Cooley (b. 1927)