Isoforms
At least six major types (different N termini) of neuregulin 1 are known. Six types exist in humans and rodents (type I, II and III NRG1 are expressed in excitatory and inhibitory neurons, as well as astrocytes), and some types (I and IV) can be regulated by neuronal activity.
| type | aliases |
|---|---|
| I | Heregulin, NEU differentiation factor (NDF), or acetylcholine receptor inducing activity (ARIA) |
| II | Glial Growth Factor-2 (GGF2) |
| III | Sensory and motor neuron-derived factor (SMDF) |
| IV | |
| V | |
| VI |
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