The neural fold is a structure that arises during neurulation in the embryonic development of both birds and mammals among other organisms. This structure is associated with primary neurulation, meaning that it forms by the coming together of tissue layers, rather than a clustering, and subsequent hollowing out, of individual cells (known as secondary neurulation). In humans, the neural folds are responsible for the formation of the anterior end of the neural tube. The neural folds are derived from the neural plate, a preliminary structure consisting of elongated ectoderm cells. The folds give rise to neural crest cells, as well as bringing about the formation of the neural tube.
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Famous quotes containing the word fold:
“I mourn the safe and motherly old middle-class queen, who held the nation warm under the fold of her big, hideous Scotch-plaid shawl and whose duration had been so extraordinarily convenient and beneficent. I felt her death much more than I should have expected; she was a sustaining symbol—and the wild waters are upon us now.”
—Henry James (1843–1916)