Pain
While large mechanosensory neurons such as type I/group Aß display adaptation, smaller type IV/group C nociceptive neurons do not. As a result, pain does not usually subside rapidly but persists for long periods of time; in contrast, one quickly stops receiving touch or sensory information if surroundings remain constant.
Read more about this topic: Neural Adaptation
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—Henry David Thoreau (1817–1862)