Role in Disease
Interest in MOG has centered on its role in demyelinating diseases, such as adrenoleukodystrophy, vanishing white matter disease, multiple sclerosis (MS) and Rubella induced mental retardation. It is a target antigen that leads to autoimmune-mediated demyelation. MOG has received much of its laboratory attention in studies dealing with MS. Several studies have shown a role for antibodies against MOG in the pathogenesis of MS. Animal models of MS, EAE, have shown that “MOG-specific EAE models (of different animal strains) display/mirror human multiple sclerosis", as is demonstrated by the demyelinating capacity and by the topography of the lesions. These models have shown that the anti-MOG antibodies are the cause of the demyelination. These models with anti-MOG antibodies have been investigated extensively and “are the only antibodies with demyelinating capacity”.
Read more about this topic: Myelin Oligodendrocyte Glycoprotein
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