Murillo may refer to:-
- Places
- Murillo, Ontario a Canadian township named after Bartolomé Esteban Murillo
- Murillo, Tolima a Colombian town
- Murillo de Gállego a municipality in Zaragoza, Aragon, Spain
- People
- Ander Murillo, a Spanish football (soccer) player
- Bartolomé Esteban Murillo, a seventeenth century Spanish artist
- Juan Murillo, a Venezuelan road cyclist
- Manuel Murillo Toro, a nineteenth century Colombian president and writer
- Marino Murillo, a Cuban communist official
- Pedro Domingo Murillo, independentist leader of Bolivia
- Fernando Ramírez de Haro, 15th Count of Murillo, Spanish aristocrat
- Buildings
- Murillo Flats, listed on the National Register of Historic Places in Polk County, Iowa
- Transportation
- SS Murillo, a refrigerated cargo ship in service with Lamport & Holt Line 1946-52