Mucoepidermoid Carcinoma - Molecular Biology

Molecular Biology

Mucoepidermoid carcinomas of the salivary and bronchial glands are characterized by a recurrent t(11;19)(q21;p13) chromosomal translocation resulting in a MECT1-MAML2 fusion gene. The CREB-binding domain of the CREB coactivator MECT1 (also known as CRTC1, TORC1 or WAMTP1) is fused to the transactivation domain of the Notch coactivator MAML2 PMID 16444749.

A possible association with papillomavirus has been reported.

Read more about this topic:  Mucoepidermoid Carcinoma

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