Interactions
MSX1 has been shown to interact with DLX5, CREB binding protein, Sp1 transcription factor, DLX2, TATA binding protein and Msh homeobox 2.
LHX2, a LIMtype homeoprotein, is a protein partner for MSX1 in vitro and in cellular extracts. The interaction between MSX1 and LHX2 is mediated through the homeodomain-containing regions of both proteins. MSX1 and LHX2 form a protein complex in the absence of DNA, and that DNA binding by either protein alone can occur at the expense of protein complex formation.
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The expression patterns of Msx1 and Lhx2 overlap during murine development. In situ hybridization was performed on adjacent sections from day 11.5 p. c. mouse embryos using Msx1 (A, B) or Lhx2 (C, D) antisense probes. A, C Transverse sections at the mid-thoracic level showing overlapping expression (arrows) of Msx1 and Lhx2 in the limb buds (Lb). B, D Higher magnification of A and C showing that Msx1 and Lhx2 are coexpressed throughout the distal limb mesenchyme (arrows), although Lhx2 is excluded from the apical ectodermal ridge (AER).
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