MPT may refer to:
- Maintenance and Protection of Traffic (MPT)
- Male Pipe Thread (a.k.a. MIP or Male Iron Pipe), a National pipe thread connection to an FPT (Female Pipe Thread) or equivalently an FIP (Female Iron Pipe)
- Mario Power Tennis, a video game for the Nintendo GameCube
- Marko Perković Thompson, a Croatian singer
- Maryland Public Television, the public television broadcaster for Maryland, USA
- Master of Physical Therapy, a post-baccalaureate professional degree conferred upon physical therapists
- Master Piano Technicians of America, (MPT) an association of professional piano technicians
- Mental Performance Training, sometimes marketed as Combat Brain Training, a neuro-plastic re-engineering brain training program originally created for DOD
- Metroid Prime: Trilogy, a compilation video game for the Wii console
- Microwave Power Transmission
- Mid Pleistocene Transition (MPT)
- Ministry of Posts and Telecommunications, early UK radio/telephone regulatory department, since 2003 Ofcom has performed its functions
- Ministry of Posts and Telecommunications, China post and telecom regulatory and operation entity before the reform. Replaced by MII and then by MIIT.
- Mitochondrial permeability transition, a loss of impermeability of the membranes of mitochondria that occurs under some pathological conditions such as traumatic brain injury
- Mobile PhoneTools, a program allows certain cellphones to connect with personal computers
- Modern portfolio theory, in finance and financial economics
- ModPlug Tracker, tracker software
- Morpeth railway station, England; National Rail station code MPT
- Multistate Performance Test, having to do with the profession of law in the United States of America
- Methylpropyltryptamine, a psychedelic tryptamine
- Tetrahydromethanopterin, the coenzyme H4MPT
- Molybdopterin, a component of molybdenum cofactor
- Multi-Purpose Tactical, a type of bullet
- Myanmar Post and Telecommunications, a state-owned internet service provider in Myanmar/Burma
- Modern Periodic Table, of elements
- MPact-Thales, a consortium composed of VolkerRail, Laing O’Rourke, and the Thales Group