MPF may refer to:
- Malta Police Force, the national police force of Malta
- Mauritius Police Force, the national police force of the Republic of Mauritius
- Myanmar Police Force, the national police force of Myanmar (Burma)
- Managed Package Framework, Microsoft technology
- Mandatory Provident Fund, pension scheme of Hong Kong
- Married Partner Fetishism, a sexual fetish of a single male/female for a married partner, often stemming from a workplace environment
- Mars Pathfinder, the NASA Mars lander
- Maturation promoting factor, also called mitosis-promoting factor, in cell biology, a regulatory molecule in the growth cycle of cells composed of cyclin and cyclin-dependent kinase
- Metallic Path Facilities, a telecommunications term
- Movement for France (French political party)
- Multi-Picture Format, a Camera & Imaging Products Association standard for some JPEG files in one
- Multi-Purpose Food, a nutritional product
- Multiphase Flow in fluid mechanics
- Sodium monofluorophosphate an inorganic compound.
- Mediaroom Presentation Framework an IPTV Framework