Double and Triple MAT Agents (aka SNRIs and TRIs)
Below are examples of drugs that act directly by inhibiting two or more MATs simultaneously. Serotonin-norepinephrine re-uptake inhibitors (SNRIs) act by blocking both SERTs and NETs. Triple re-uptake inhibitors (TRIs) act by blocking DATs, NETs, and SERTs simultaneously. Most modern antidepressant drugs work on the principal of blocking re-uptake transporters. SSRI's such as Fluoxetine (Prozac) and SNRI's as with Venlafaxine are the main types of drugs given in first line depression and anxiety treatment.
- PRC200-SS is an example of an SNRI.
- JNJ-7925476 is an example of a TRI
- nocaine-modafinil hybrids such as 16e
- Blough (2002) showed that MATs exhibit a "remote phenyl binding domaine"
Read more about this topic: Monoamine Transporter
Famous quotes containing the words double, triple, mat and/or agents:
“Freedom in art, freedom in society, this is the double goal towards which all consistent and logical minds must strive.”
—Victor Hugo (1802–1885)
“And DANTE searched the triple spheres,
Moulding nature at his will,
So shaped, so colored, swift or still,
And, sculptor-like, his large design
Etched on Alp and Apennine.”
—Ralph Waldo Emerson (1803–1882)
“Or on the Mat devoutly kneeling
Would lift her Eyes up to the Ceiling,
And heave her Bosom unaware
For neighb’ring Beaux to see it bare.”
—Jonathan Swift (1667–1745)
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—George F. Will (b. 1941)