Double and Triple MAT Agents (aka SNRIs and TRIs)
Below are examples of drugs that act directly by inhibiting two or more MATs simultaneously. Serotonin-norepinephrine re-uptake inhibitors (SNRIs) act by blocking both SERTs and NETs. Triple re-uptake inhibitors (TRIs) act by blocking DATs, NETs, and SERTs simultaneously. Most modern antidepressant drugs work on the principal of blocking re-uptake transporters. SSRI's such as Fluoxetine (Prozac) and SNRI's as with Venlafaxine are the main types of drugs given in first line depression and anxiety treatment.
- PRC200-SS is an example of an SNRI.
- JNJ-7925476 is an example of a TRI
- nocaine-modafinil hybrids such as 16e
- Blough (2002) showed that MATs exhibit a "remote phenyl binding domaine"
Read more about this topic: Monoamine Transporter
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