Double and Triple MAT Agents (aka SNRIs and TRIs)
Below are examples of drugs that act directly by inhibiting two or more MATs simultaneously. Serotonin-norepinephrine re-uptake inhibitors (SNRIs) act by blocking both SERTs and NETs. Triple re-uptake inhibitors (TRIs) act by blocking DATs, NETs, and SERTs simultaneously. Most modern antidepressant drugs work on the principal of blocking re-uptake transporters. SSRI's such as Fluoxetine (Prozac) and SNRI's as with Venlafaxine are the main types of drugs given in first line depression and anxiety treatment.
- PRC200-SS is an example of an SNRI.
- JNJ-7925476 is an example of a TRI
- nocaine-modafinil hybrids such as 16e
- Blough (2002) showed that MATs exhibit a "remote phenyl binding domaine"
Read more about this topic: Monoamine Transporter
Famous quotes containing the words double, triple, mat and/or agents:
“The worst feature of this double consciousness is, that the two lives, of the understanding and of the soul, which we lead, really show very little relation to each other; never meet and measure each other: one prevails now, all buzz and din; and the other prevails then, all infinitude and paradise; and, with the progress of life, the two discover no greater disposition to reconcile themselves.”
—Ralph Waldo Emerson (1803–1882)
“And we fairies, that do run
By the triple Hecate’s team
From the presence of the sun,
Following darkness like a dream,
Now are frolic. Not a mouse
Shall disturb this hallowed house.”
—William Shakespeare (1564–1616)
“Or on the Mat devoutly kneeling
Would lift her Eyes up to the Ceiling,
And heave her Bosom unaware
For neighb’ring Beaux to see it bare.”
—Jonathan Swift (1667–1745)
“Even though fathers, grandparents, siblings, memories of ancestors are important agents of socialization, our society focuses on the attributes and characteristics of mothers and teachers and gives them the ultimate responsibility for the child’s life chances.”
—Sara Lawrence Lightfoot (20th century)