Moffit or Moffitt may refer to:
- H. Lee Moffitt Cancer Center & Research Institute, University of South Florida, Tampa
- Moffitt architecture, a vernacular house style in the U.S.
- Moffitt Library, University of California, Berkeley
- Moffitt Royal Commission, a royal commission to investigate the extent and activities of organised crime in the state of New South Wales, Australia
- Mount Moffit, Alaska
- Moffit, North Dakota
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