A very short time after Charles Limekiller's disappearance, a little old lady named Lola Limekiller appeared for a while in the strip. Her relation to the original Limekiller was never explained.
She is a radical environmental activist and good friends with the cockroaches in her kitchen. It is possible she was intended as a reworking of Milo's grandmother, Bess. She only appeared during the latter half of a story arc where Opus, thinking he'd booked passage on a pleasure cruise to Antarctica, instead wound up aboard the Rainbow Warrior on an anti-whaling mission.
Read more about this topic: Minor Characters In Bloom County