Minimal Residual Disease - Treatment

Treatment

Generally the approach is to bring a cancer into remission first (absence of symptoms) and then try to eradicate the remaining cells (MRD). Often the treatments needed to eradicate MRD differ from those used initially. This is an area of much research.

It seems a sensible idea to aim to reduce or eradicate MRD. What is needed is evidence on which is the best method, and how well it works. This is emerging. Treatments which specifically target MRD can include:

  • intensive conventional treatment with more drugs, or a different combination of drugs
  • stem cell transplant, e.g. marrow transplant. This allows more intensive chemotherapy to be given, and in addition the transplanted bone marrow may help eradicate the minimal residual disease
  • immunotherapy
  • monitoring the patient carefully for early signs of relapse. This is an area of active research in several countries.
  • treatment with monoclonal antibodies which target cancer cells
  • cancer vaccines

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Famous quotes containing the word treatment:

    I will use treatment to help the sick according to my ability and judgment, but never with a view to injury and wrongdoing. Neither will I administer a poison to anybody when asked to do so, nor will I suggest such a course. Similarly, I will not give to a woman a pessary to cause abortion. I will keep pure and holy both my life and my art.
    Hippocrates (c. 460–c. 370 B.C.)

    James’s great gift, of course, was his ability to tell a plot in shimmering detail with such delicacy of treatment and such fine aloofness—that is, reluctance to engage in any direct grappling with what, in the play or story, had actually “taken place”Mthat his listeners often did not, in the end, know what had, to put it in another way, “gone on.”
    James Thurber (1894–1961)

    Any important disease whose causality is murky, and for which treatment is ineffectual, tends to be awash in significance.
    Susan Sontag (b. 1933)