Organization of MTOC in Cells
Microtubule-organizing centers function as the site where microtubule formation begin, as well as a location where free-ends of microtubules attract to. Within the cells, microtubule-organizing centers can take on many different forms. An array of microtubules can arrange themselves in a pinwheel structure to form the basal bodies, which can lead to the formation of microtubule arrays in the cytoplasm or the 9+2 axoneme. Other arrangements range from fungi spindle pole bodies to the eukaryotic chromosal kinetochores (flat, laminated plaques). MTOCs can be freely dispersed throughout the cytoplasm or centrally localized as foci. The most notable MTOCs are the centrosome at interphase and the mitotic spindle poles.
Centrioles can act as markers for MTOCs in the cell. If they are freely distributed in the cytoplasm, centrioles can gather during differentiation to become MTOCs. They can also be focused around a centrosome as a single MTOC, though centrosomes can work as an MTOC absent of centrioles.
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