Merlin (protein)
Gene Ontology | |
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Molecular function | • protein binding • cytoskeletal protein binding |
Cellular component | • nucleus • nucleolus • cytoplasm • early endosome • cytoskeleton • plasma membrane • adherens junction • extrinsic to membrane • lamellipodium • cortical actin cytoskeleton • filopodium membrane • cleavage furrow • ruffle membrane • perinuclear region of cytoplasm |
Biological process | • mesoderm formation • negative regulation of cell-matrix adhesion • negative regulation of protein kinase activity • ectoderm development • negative regulation of DNA replication • negative regulation of cell proliferation • Schwann cell proliferation • negative regulation of cell-cell adhesion • actin cytoskeleton organization • negative regulation of cell migration • regulation of hippo signaling cascade • odontogenesis of dentin-containing tooth • negative regulation of tyrosine phosphorylation of Stat3 protein • negative regulation of tyrosine phosphorylation of Stat5 protein • negative regulation of MAPK cascade • cell-cell junction organization • negative regulation of JAK-STAT cascade • positive regulation of stress fiber assembly • lens fiber cell differentiation |
Sources: Amigo / QuickGO |
30 – 30.09 Mb
4.77 – 4.85 Mb
Merlin (also called Neurofibromin 2 or schwannomin) is a cytoskeletal protein. In humans, it is a tumor suppressor protein involved in Neurofibromatosis type II. Sequence data reveal its similarity to the ERM protein family.
The name "merlin" is an acronym for "Moesin-Ezrin-Radixin-Like Protein".
Read more about Merlin (protein): Gene, Structure, Function, Interactions
Famous quotes containing the word merlin:
“Of Merlin wise I learned a song,
Sing it low, or sing it loud,
It is mightier than the strong,
And punishes the proud.”
—Ralph Waldo Emerson (18031882)