Merlin (protein)

Merlin (protein)

Identifiers Symbols NF2; ACN; BANF; SCH External IDs OMIM: 607379 MGI: 97307 HomoloGene: 2180 GeneCards: NF2 Gene

Gene Ontology
Molecular function	• protein binding • cytoskeletal protein binding
Cellular component	• nucleus • nucleolus • cytoplasm • early endosome • cytoskeleton • plasma membrane • adherens junction • extrinsic to membrane • lamellipodium • cortical actin cytoskeleton • filopodium membrane • cleavage furrow • ruffle membrane • perinuclear region of cytoplasm
Biological process	• mesoderm formation • negative regulation of cell-matrix adhesion • negative regulation of protein kinase activity • ectoderm development • negative regulation of DNA replication • negative regulation of cell proliferation • Schwann cell proliferation • negative regulation of cell-cell adhesion • actin cytoskeleton organization • negative regulation of cell migration • regulation of hippo signaling cascade • odontogenesis of dentin-containing tooth • negative regulation of tyrosine phosphorylation of Stat3 protein • negative regulation of tyrosine phosphorylation of Stat5 protein • negative regulation of MAPK cascade • cell-cell junction organization • negative regulation of JAK-STAT cascade • positive regulation of stress fiber assembly • lens fiber cell differentiation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 4771 18016 Ensembl ENSG00000186575 ENSMUSG00000009073 UniProt P35240 P46662 RefSeq (mRNA) NM_000268.3 NM_001252250.1 RefSeq (protein) NP_000259.1 NP_001239179.1 Location (UCSC) Chr 22:
30 – 30.09 Mb Chr 11:
4.77 – 4.85 Mb PubMed search

Merlin (also called Neurofibromin 2 or schwannomin) is a cytoskeletal protein. In humans, it is a tumor suppressor protein involved in Neurofibromatosis type II. Sequence data reveal its similarity to the ERM protein family.

The name "merlin" is an acronym for "Moesin-Ezrin-Radixin-Like Protein".