Validation
The MCI Screen was validated in a study on 471 community dwelling adults whose scores on the Clinical Dementia Rating Scale ranged from 0 (normal: N=119), 0.5 (mild cognitive impairment: N=95), to 1 (mild dementia: N=257). According to a 2005 publication in The Proceedings of the National Academy of Sciences, the MCI Screen has overall accuracy of 98% with sensitivity of 97% for mild cognitive impairment or mild dementia, and 88% specificity for normal aging. Clinical studies in the USA have shown that the MCI Screen detects early-stage, memory loss due to multiple underlying medical conditions including Alzheimer's disease, cerebrovascular disease, and others. Japan based studies have demonstrated cross-cultural validity of the MCI Screen in clinical and academic settings with accuracy levels equal to those in the USA.
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