Revised Diagnostic Criteria (2010)
Clinical Presentation | Additional Data Needed |
---|---|
* 2 or more attacks (relapses) * 2 or more objective clinical lesions |
None; clinical evidence will suffice (additional evidence desirable but must be consistent with MS) |
* 2 or more attacks * 1 objective clinical lesion |
Dissemination in space, demonstrated by: * MRI * or a positive CSF and 2 or more MRI lesions consistent with MS * or further clinical attack involving different site. New criteria: Dissemination in Space (DIS) can be demonstrated by the presence of 1 or more T2 lesions in at least 2 of 4 of the following areas of the CNS: Periventricular, Juxtacortical, Infratentorial, or Spinal Cord. |
* 1 attack * 2 or more objective clinical lesions |
Dissemination in time (DIT), demonstrated by: * MRI * or second clinical attack New criteria: No longer a need to have separate MRIs run; Dissemination in time, demonstrated by: Simultaneous presence of asymptomatic gadolinium-enhancing and nonenhancing lesions at any time; or A new T2 and/or gadolinium-enhancing lesion(s) on follow-up MRI, irrespective of its timing with reference to a baseline scan; or Await a second clinical attack. |
* 1 attack * 1 objective clinical lesion (clinically isolated syndrome) |
New criteria: Dissemination in space and time, demonstrated by:
For DIS: 1 or more T2 lesion in at least 2 of 4 MS-typical regions of the CNS (periventricular, juxtacortical, infratentorial, or spinal cord); or Await a second clinical attack implicating a different CNS site; and For DIT: Simultaneous presence of asymptomatic gadolinium-enhancing and nonenhancing lesions at any time; or A new T2 and/or gadolinium-enhancing lesion(s) on follow-up MRI, irrespective of its timing with reference to a baseline scan; or Await a second clinical attack. |
Insidious neurological progression suggestive of MS (primary progressive MS) |
New criteria: One year of disease progression (retrospectively or prospectively determined) and
two or three of the following: |
Read more about this topic: McDonald Criteria
Famous quotes containing the words revised and/or criteria:
“Coming to Rome, much labour and little profit! The King whom you seek here, unless you bring Him with you you will not find Him.”
—Anonymous 9th century, Irish. Epigram, no. 121, A Celtic Miscellany (1951, revised 1971)
“We should have learnt by now that laws and court decisions can only point the way. They can establish criteria of right and wrong. And they can provide a basis for rooting out the evils of bigotry and racism. But they cannot wipe away centuries of oppression and injusticehowever much we might desire it.”
—Hubert H. Humphrey (19111978)