Mayes is a surname, and may refer to:
- Adrian Mayes, American football player
- Alan Mayes (born 1953), English footballer
- Bernard Mayes, British-American lecturer and author
- Clyde Mayes (born 1953), American professional basketball player
- Colin Mayes (born 1948), Canadian politician
- Derrick Mayes (born 1974), American football player
- Frances Mayes (born 1940), American university professor, poet, memoirist, essayist, and novelist
- Ian Mayes, British journalist and editor
- Jeff Mayes, American politician
- Joel B. Mayes (died 1891), Chief of the Cherokee Nation
- John Mayes, Australian rugby league player
- L J Mayes, English author, historian and folk song collector
- Richard Mayes (1922 - 2006), English stage and television actor
- Rueben Mayes (born June 6, 1963), Canadian football player
- Rufus Mayes (born 1947), American football player
- Samuel Houston Mayes, Chief of the Cherokee Nation from 1895 to 1899
- Sean Mayes (1949-1995), English rock musician and author
- Wendell Wise Mayes, Jr.
- William Mayes, Jr., prominent pirate, proprietor of White Horse Tavern (Rhode Island)
- William Edward Mayes (1861 – 1952), English painter