Structure
| Scorpion short toxin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Margatoxin. Disulphide bonds are highlighted. PDB 1mtx | |||||||||
| Identifiers | |||||||||
| Symbol | Toxin_2 | ||||||||
| Pfam | PF00451 | ||||||||
| Pfam clan | CL0054 | ||||||||
| InterPro | IPR001947 | ||||||||
| PROSITE | PDOC00875 | ||||||||
|
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Margatoxin is a peptide of 39 amino acids with a molecular weight of 4185 Dalton. The primary amino acid sequence of Margatoxin is as follows: Thr-Ile-Ile-Asn-Val-Lys-Cys-Thr-Ser-Pro-Lys-Gln-Cys-Leu-Pro-Pro-Cys-Lys-Ala-Gln-Phe-Gly-Gln-Ser-Ala-Gly-Ala-Lys-Cys-Met-Asn-Gly-Lys-Cys-Lys-Cys-Tyr-Pro-His. There are disulfide bridges between Cys 7-Cys29, Cys13-Cys34 and Cys17-Cys36.
Margatoxin is classified as a 'Scorpion short toxin' by Pfam, showing sequence homology with other potassium channel blockers, such as charybdotoxin (44%), kaliotoxin (54%), iberiotoxin (41%) and noxiustoxin (79%), which are also derived from scorpion venom.
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