Mannan-binding Lectin

Mannan-binding Lectin

Identifiers Symbols MBL2; COLEC1; HSMBPC; MBL; MBL2D; MBP; MBP-C; MBP1 External IDs OMIM: 154545 MGI: 96924 HomoloGene: 110436 ChEMBL: 1795113 GeneCards: MBL2 Gene

Gene Ontology
Molecular function	• receptor binding • protein binding • mannose binding • eukaryotic cell surface binding • calcium-dependent protein binding • bacterial cell surface binding
Cellular component	• extracellular region • collagen • extracellular space
Biological process	• complement activation, lectin pathway • acute-phase response • complement activation • complement activation, classical pathway • response to oxidative stress • opsonization • negative regulation of growth of symbiont in host • innate immune response • positive regulation of phagocytosis • defense response to Gram-positive bacterium • killing by host of symbiont cells
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 4153 17195 Ensembl ENSG00000165471 ENSMUSG00000024863 UniProt P11226 P41317 RefSeq (mRNA) NM_000242.2 NM_010776.1 RefSeq (protein) NP_000233.1 NP_034906.1 Location (UCSC) Chr 10:
54.53 – 54.53 Mb Chr 19:
30.23 – 30.24 Mb PubMed search

Mannose-binding lectin (MBL), also called mannose-binding protein or mannan-binding protein (MBP), is a lectin that is instrumental in innate immunity.