Manistee may refer to:
- Manistee, Michigan
- Manistee County, Michigan
- Manistee County-Blacker Airport
- Manistee Township, Michigan
- Manistee National Forest, jointly administered as part of the Huron-Manistee National Forests in Michigan
- Manistee River, Michigan
- Manistee Light, at the mouth of the river
- Manistee Railroad, Michigan
- SS Manistee, Second World War-era merchant vessel
- USS Manistee (YT-173) US Navy tugboat
- USS Manistee (YTB-782) US Navy tugboat