Aging
Decreased TOR activity has been found to slow aging in S. cerevisiae, C. elegans, and D. melanogaster. The mTOR inhibitor rapamycin has been confirmed to increase lifespan in mice by independent groups at the Jackson Laboratory, University of Texas Health Science Center, and the University of Michigan.
It's hypothesized that some dietary regimes, like caloric restriction and methionine restriction, cause lifespan extension by decreasing mTOR activity. But infusion of leucine into the rat brain has been shown to decrease food intake and body weight via activation of the mTOR pathway.
Read more about this topic: Mammalian Target Of Rapamycin
Famous quotes containing the word aging:
“The politics of the exile are fever,
revenge, daydream,
theater of the aging convalescent.
You wait in the wings and rehearse.
You wait and wait.”
—Marge Piercy (b. 1936)
“Bourbon’s the only drink. You can take all that champagne stuff and pour it down the English Channel. Well, why wait 80 years before you can drink the stuff? Great vineyards, huge barrels aging forever, poor little old monks running around testing it, just so some woman in Tulsa, Oklahoma can say it tickles her nose.”
—John Michael Hayes (b.1919)
“You are truly the generation in the middle! You have at once aging parents as well as maturing children to cope with, and you are not granted the deference accorded age, or the indulgence given the young.”
—Helene S. Arnstein (20th century)