Treatment
If the disease is limited to the stomach (which is assessed with computed tomography), then 70–80% of patients will have a complete regression on treatment with antibiotic eradication of H. pylori.
Others may be effectively controlled with the use of radiotherapy, or surgery. Both modalities may be curative in localized disease.
In contrast, if the disease has spread or has been refractory on antibiotics, chemotherapy may need to be considered.
A t(11;18)(q21;q21) chromosomal translocation, giving rise to a API2-MLT fusion gene, is predictive of poor response to eradication therapy.
Two other genetic alterations are known:
- t(1;14)(p22;q32) which deregulates BCL10, at the locus 1p22.
- t(14;18)(q32;q21), which deregulates MALT1, at the locus 18q21.
These seem to turn-on the same pathway as API2-MLT (i.e., that of NF-κB). They both act upon IGH, which is at the locus 14q32.
Read more about this topic: MALT Lymphoma
Famous quotes containing the word treatment:
“If the study of all these sciences, which we have enumerated, should ever bring us to their mutual association and relationship, and teach us the nature of the ties which bind them together, I believe that the diligent treatment of them will forward the objects which we have in view, and that the labor, which otherwise would be fruitless, will be well bestowed.”
—Plato (c. 427–347 B.C.)
“Any important disease whose causality is murky, and for which treatment is ineffectual, tends to be awash in significance.”
—Susan Sontag (b. 1933)
“Our treatment of both older people and children reflects the value we place on independence and autonomy. We do our best to make our children independent from birth. We leave them all alone in rooms with the lights out and tell them, “Go to sleep by yourselves.” And the old people we respect most are the ones who will fight for their independence, who would sooner starve to death than ask for help.”
—Margaret Mead (1901–1978)