Maintenance Dose - Calculating The Maintenance Dose

Calculating The Maintenance Dose

The required maintenance dose may be calculated as:

Where:

MD is the maintenance dose rate
Cp = desired peak concentration of drug
CL = clearance of drug in body
F = bioavailability

For an intravenously administered drug, the bioavailability F will equal 1, since the drug is directly introduced to the bloodstream. If the patient requires an oral dose, bioavailability will be less than 1 (depending upon absorption, first pass metabolism etc.), requiring a larger loading dose.

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