Fictional Characters
- Buford "Mad Dog" Tannen, from the movie Back to the Future Part III
- nickname of Wayne Dobie in the film Mad Dog and Glory
- Mad Dog, from the John Woo film Hard Boiled
- Mad Dog Rassitano, a bounty hunter and former SWAT team member in the Marvel Universe
- Mad Dog (comics), an assassin in the DC Universe
- Johnny Mad Dog, from the film by Jean-Stéphane Sauvaire
- Mad Dog, from the movie Ong Bak, starring Tony Jaa
- Mad Dog, from the movie The Raid: Redemption, starring Iko Uwais
- Mad Dog Branzillo, in the book A Swiftly Tilting Planet by Madeleine L'Engle
- Tim Johnson, from To Kill a Mockingbird by Harper Lee
- Sgt. Mick Belker, a detective sometimes referred to as "Mad Dog" due to his habits of growling and biting like a dog from the television series Hill Street Blues
- Bill Rizer in the American localization of Contra (video game) and Super Contra for the Nintendo Entertainment System
- a different character of that name in Contra 4 for the Nintendo DS
- Madd Dogg, a character played by Ice-T in the video game Grand Theft Auto: San Andreas
- Tommy "Mad Dog" McCulum, from the South African TV series Isidingo, played by David James
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