Rigid-body Docking vs. Flexible Docking
If the bond angles, bond lengths and torsion angles of the components are not modified at any stage of complex generation, it is known as rigid body docking. A subject of speculation is whether or not rigid-body docking is sufficiently good for most docking. When substantial conformational change occurs within the components at the time of complex formation, rigid-body docking is inadequate. However, scoring all possible conformational changes is prohibitively expensive in computer time. Docking procedures which permit conformational change, or flexible docking procedures, must intelligently select small subset of possible conformational changes for consideration.
Read more about this topic: Macromolecular Docking
Famous quotes containing the word flexible:
“It is safest to be moderately base—to be flexible in shame, and to be always ready for what is generous, good and just, when anything is to be gained by virtue.”
—Sydney Smith (1771–1845)