Macedo may refer to:
- Macedo (musical group), American musical group featuring twin sisters Michelle and Melissa Macedo
- António Macedo (born 1931), Portuguese film director
- Carlos Macedo (born 1965), member of the professional Portuguese theater company KlássiKus
- Edir Macedo (born 1945), religious leader
- Jean Carlos Macedo da Silva (born 1980), Brazilian attacking-midfielder
- Joílson Rodrigues Macedo (born 1979), Brazilian right back
- José Macedo, Peruvian politician
- José Macedo Vieira (born 1949), president of the city council of Póvoa de Varzim
- Leandro Macedo (born 1968), athlete
- Manuel Lepe Macedo (1936-1984), Mexican artist
- Rafael Macedo de la Concha (born 1950), Mexican army general and former Attorney General
- Stephen Macedo, director for the Center for Human Values at Princeton University