Mac Giolla is an Irish surname shared by several notable people:
- Tomás Mac Giolla (1924–2010), former Irish member of parliament
- Antoine Mac Giolla Bhrighde (1957–1984), Provisional Irish Republican Army (IRA) volunteer
- Brian Mac Giolla Phádraig (c. 1580–c. 1652), Irish scholar and poet
- Cathal Buí Mac Giolla Ghunna (c. 1680–1756), Irish poet
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