Lorenzetti is an Italian surname and may refer to:
- Ambrogio Lorenzetti - Sienese painter
- Enrico Lorenzetti - Italian moto GP racer of the 1940s and 1950s
- Pietro Lorenzetti - Sienese painter, brother of Ambrogio Lorenzetti
- Ricardo Lorenzetti - current president elect of the Argentine Supreme Court of Justice
- Ricardo Lorenzetti - current president elect of the Argentine Supreme Court of Justice
- Gustavo Lorenzetti - is an Argentine footballer