Lofton is a surname, and may refer to:
In sports:
- Chris Lofton (born 1986), American basketball player
- Curtis Lofton (born 1986), American football linebacker
- David Lofton (born 1984), American football safety
- James Lofton, former American Football wide receiver and coach
- James Lofton (baseball), former Major League Baseball shortstop
- Kenny Lofton, Major League Baseball outfielder
- Oscar Lofton, college football head coach
- Steve Lofton (born 1968), American football cornerback
In other fields:
- Cirroc Lofton, American actor
- Cripple Clarence Lofton (1887–1957)
- Julie Lofton, American new media social entrepreneur
- John Lofton, American political commentator
- Melanie Lofton, American Journalist
- Ramona Lofton, African-American author and performance poet
- Saab Lofton, author and radio personality