Locus Coeruleus - Function

Function

It is related to many functions via its widespread projections. The LC-NA system modulates cortical, subcortical, cerebellar, brainstem and spinal cord circuits. Some of the most important functions influenced by this system are :

Neuroplasticity

Arousal and sleep-wake cycle

Attention and memory

Emotions

Behavioral flexibility, behavioral inhibition and stress (psychological)

Posture and balance.

The locus coeruleus may figure in clinical depression, panic disorder, and anxiety. Some medications including norepinephrine reuptake inhibitors (reboxetine, atomoxetine), serotonin-norepinephrine reuptake inhibitors (venlafaxine, duloxetine), and norepinephrine-dopamine reuptake inhibitors (bupropion) are believed to show efficacy by acting upon neurons in this area.