Target Genes
Target genes of LXRs are involved in cholesterol and lipid metabolism regulation, including:
- ABC - ATP Binding Cassette transporter isoforms A1, G1, G5, and G8
- ApoE - Apolipoprotein E
- CETP - CholEsterylester Transfer Protein
- FAS - Fatty Acid Synthase
- CYP7A1 - CYtochrome P450 isoform 7A1 - cholesterol 7α-hydroxylase
- LPL - LipoProtein Lipase
- LXR-α - Liver X Receptor-α (a somewhat unusual example of receptor up-regulating its own expression)
- SREBP-1c - Sterol Regulatory Element Binding Protein 1c
- ChREBP - Carbohydrate Regulatory Element Binding Protein
Read more about this topic: Liver X Receptor
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